Drunk Drivers Make Me Sad

I normally curse reckless drivers and hope they get what’s coming to them. Except for tonight. This driver was being far too reckless — and I was concerned for them.

A really nice silver car came zooming along in the carpool lane, engine furious, moving at least 35 miles per hour faster than anyone else on the bridge. The driver then cut in front of three cars in front of me and in the next lane over while changing into the rightmost lane. What really concerned me was how fast he was approaching the car ahead of him. Both cars disappeared around exit onto 14E towards Camas, WA — my exit also.

I followed them, lagging by about a minute. I was almost expecting an accident as I exited the I-5N to head east. I saw an intact tire towards the side of the road and I swerved to avoid it. I saw smoke. Then I saw glass. I braced to see the worst.

Ahead, a car had pulled over. It’s emergency blinkers flashed. Further ahead and opposite the tire, the silver car lay upside down without a tire on the front driver’s side and the back angled up towards the air.

As I passed the upside down car, I noticed the driver moving trying to get out. I drove about a hundred feet ahead and pulled over. Other cars were starting to pull over as well. I was walking up to the silver car with my cell phone in hand and 911 already keyed in. I saw the driver get out of the car. He said, “I’m alright.” He then proceeded to tell me that he had a few drinks and that he wanted to leave and asked if I would give him a ride a few exits toward the hospital. I said that I would, but really intended to call 911.

He turned around and went back to his car. As I turned to look at my car and dial, another car pulled over slightly ahead of me and behind my car. I heard a crash behind me and whipped around to see that another car had been hit by a truck right by the silver car’s tire. Two people got out of the Jeep that just pulled over and asked if I had dialed 911 as my finger had pushed the call button and I told them, “I’m calling right now”. I spoke with dispatch to tell them where this was happening — just north of the I-5 bridge on the off ramp to 14E. She told me that a team was on the way.

A guy wearing black came to have a look at the people involved in the accidents. This man was a Navy medic. He inspected the driver and thought he might have a concussion from the forehead and temple injuries. There was also a nurse who was doing an assessment on some of the people closer to the secondary accident.

An ambulance, fire truck, highway patrol officer and a local sheriff arrived just a few minutes afterward. The emergency crew responded to the secondary accident. The lady in the car that was hit in the rear was slowly extracted from the car and put into a stretcher and loaded into the ambulance. The silver car’s driver, suspected of intoxication and possibly marijuana (he was in possession of a pipe, which was laying in the open with his stuff), was being examined by the sheriff. The police took my information and starting taking notes on my recollection. I was cleared to leave.

I was tired. I walked back to my car. I got in, started it up, and drove home.

I thought, at one time, I could have been that reckless driver. If I hadn’t had passed out and fell down as I was leaving Rotture a month ago, I could have gotten into my car and drove off. I probably wouldn’t have driven so fast, but there’s no telling what I would have done that drunk. I basically passed out that night from alcohol. If had got into my car, drove off, then passed out — I would have been in really bad shape and others might have too.

I didn’t get a chance to touch my car that night, but I still ended up in an ambulance. I woke up at OHSU the next morning and took the bus back to downtown Portland and had breakfast at the Pearl Bakery. Then I walked to my car. I still felt terrible, and probably shouldn’t have driven my car that morning. I went to my Portland office, drank water, chatted with a friend online and passed out on the futon.

I now have a great respect for alcohol and how much of a poison it is. I still drink, but I’m now really responsible about it. I don’t want to injure other people. I also don’t want to injure myself. There’s enough to worry about without having drunkenness ruin your day. The next time I hear a story about a drunk driver, I’m probably going to cry. It’s so sad that it happens, especially when it’s so preventable.

Give Your Coffee or Chocolate a Boost with Grapefruit

Why on earth am I posting on this? My blog is titled Randomness, what do you expect? Really, it’s because @brampitoyo, @rachelrigg, & @donpdonp were talking about it on twitter and I caught wind of it. I had done some research into this in the past so I knew a little bit about what grapefruit does to your metabolism. I decided I should write it out somewhere. What follows may get a little bit technical, but don’t get scared away. Anyone should be able to get the gist of this even without fully understanding the chemistry. Please heed the warning at the bottom.

Grapefruit has a few compounds in it that alter the way you digest other foods. Namely, these are bergamottin and naringenin. These compounds temporarily stop certain enzymes in your digestive pathway and in your liver (in larger doses) from breaking down certain type of compounds. These compounds include estrogens, caffeine, certain anti-depressants, and many more found here, here, and at this list of drugs affected by grapefruit Note the first two list are technical, the column heading substrate is what you need to look at. Simply because and enzyme substrate is the molecule it breaks down or builds up.

So what happens when I eat a grapefruit?

When you eat a grapefruit everything in it goes into your stomach and then to you duodenum (the small intestine) and affects the rest of what is going on there. If not much is going on there it will get into your blood stream and circulate to your liver, where it can modify what’s going on there. If you have consumed some items from the above mentioned list, eating a grapefruit will keep it being broken down into its metabolites (literally, “things thrown away”, from Greek). Meaning it will stay active longer in your body.

So then if I Drink Caffeine or Eat Chocolate…

Yes, it should have a more lasting effect. Here’s why and where it can get technical.
Look at these pictures:
A picture of Xanthine, notice the benzene ring and a pyrrole ringA caffeine molecule, notice the benzene ring and pyrrole ringTheobromine, notice the benzene ring and pyrrole ring
Xanthine,Caffeine, & Theobromine
Here’s how Caffeine breaks down:

Caffeine breaks is metabolized by enzymes into paraxanthanine, theobromine, and theophylline.
Caffeine Metabolites

All of these are in the same family of compounds. Since they’re in the same family of compounds, they should all be affected by the same enzymes. So we lookup those enzymes, CYP3A4 & CYP1A2 and it looks like they do work on a lot of things with the same structure and same R-groups.

Conclusion

So there you have it. Just mix fresh squeezed grapefruit (or anything that has the bitter skin part) into a mocha and enjoy flying around the room and the added ability to create memories and remember things. Just beware of a minor caveat — theobromine poisoning. If you have too have too much of a good thing it’ll kill you. Another thing to keep in mind is that grapefruit juice has the potential to get you more drunk and keep you there longer if you drink enough of it. So don’t go drinking coffee, grapefruit juice and alcohol — it may or may not be pleasant depending on how you roll.